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The comparison between dual inhibition of mTOR with MAPK and PI3K signaling pathways in KRAS mutant NSCLC cell lines
KRAS mutations are found in 15–25 % of patients with lung adenocarcinoma, and they lead to constitutive activation of KRAS signaling pathway that results in sustained cell proliferation. Currently, there are no direct ... -
Flavopiridol's antiproliferative effects in glioblastoma multiforme
Çobanoğlu, Gözde; Turaçlı, İrem Doğan; Özkan, Ayla Cihan; Ekmekçi, Abdullah (Wolters Kluwer Medknow Publications, 2016)Aim of Study: Glioblastoma multiforme (GBM) is largely refractory to surgical operation, radiotherapy, and chemotherapy in use today. Remaining lifetime accounting for the GBM-affected patients varies between 12 and 16 ...