Yazar "Albayrak, Gülşah" için listeleme
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Alzheimer's drug Memantine inhibits metastasis and p-Erk protein expression on 4T1 breast cancer cells
Albayrak, Gülşah; Demirtaş Korkmaz, Funda (Comenius Univ, 2020)OBJECTIVES: Drug repurposing studies enable shorter routes to the clinic by skipping the steps like in vitro in vivo screening, chemical optimization and toxicological studies. In our study, we investigated the potent ... -
Bortezomib Potentiates the Effect of Roscovitine Via Dna Damage Induced Apoptosis in A549 Lung Cancer Cells
Albayrak, Gülşah (2022)The adoption of new treatment modalities remains crucial as lung cancer has one of the lowest survival rates, along with liver and pancreatic cancer. Bortezomib is a proteasome inhibitor that has higher anticancer effect ... -
Bortezomib synergizes with nocodazole in p53 mediated DNA damage response signalling in A549 lung cancer cells
Albayrak, Gülşah (2021)The adoption of new treatment modalities is required to improve outcomes in lung cancer treatment as lung cancer has lowest survival rates, along with liver and pancreatic cancer. Bortezomib is a proteasome inhibitor that ... -
Memantine shifts cancer cell metabolism via ampk1/2 mediated energetic switch in a549 lung cancer cells
Memantine is used to prevent glutamate-mediated excitotoxicity and neurodegeneration in Alzheimer’s disease. As glutamine is one of the major source of anabolism in fast growing cancer cells, we aimed to interfere with ... -
The outcomes of an impaired powerhouse in KRAS mutant lung adenocarcinoma cells by Elesclomol
Objectives: Lung cancer stands out as the most common cancer type worldwide. The most common genetic alteration detected in adenocarcinoma patients is KRAS. KRAS mutated patients still cannot get benefit from precision ...