Yazar "Ekmekçi, Abdullah" için listeleme
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The comparison between dual inhibition of mTOR with MAPK and PI3K signaling pathways in KRAS mutant NSCLC cell lines
KRAS mutations are found in 15–25 % of patients with lung adenocarcinoma, and they lead to constitutive activation of KRAS signaling pathway that results in sustained cell proliferation. Currently, there are no direct ... -
Evaluation of in vitro fertilization parameters and estrogen receptor alpha gene polymorphisms for women with unexplained infertility
Purpose Association of ESR1 gene PvuII, XbaI and (TA)n microsatellite polymorphisms and woman infertility was evaluated. Methods Infertile(n=104) and fertile(n=107) women were included in this study. We performed ... -
Flavopiridol induces apoptosis via mitochondrial pathway in B16F10 murine melanoma cells and a subcutaneous melanoma tumor model
Gökçe, Özlem; Turaçlı, İrem Doğan; Önen, Hacer ilke; Erdem, Özlem; Kaya, Elif Ergüven; Ekmekçi, Abdullah (Croatian Dermatovenerological Society, 2016)Flavopiridol is a cyclin-dependent kinase (CDK) inhibitor that promotes cell cycle arrest. We aimed to examine the anti-proliferative effects of the flavopiridol and oxaliplatin combination on p16INK4A deficient melanoma ... -
Flavopiridol's antiproliferative effects in glioblastoma multiforme
Çobanoğlu, Gözde; Turaçlı, İrem Doğan; Özkan, Ayla Cihan; Ekmekçi, Abdullah (Wolters Kluwer Medknow Publications, 2016)Aim of Study: Glioblastoma multiforme (GBM) is largely refractory to surgical operation, radiotherapy, and chemotherapy in use today. Remaining lifetime accounting for the GBM-affected patients varies between 12 and 16 ... -
Kanserde yeni bir hedef haline gelen çok yönlü Sox2 geni
Turaçlı, İrem Doğan; Ekmekçi, Abdullah (2016)Sox2 proteini, farklılaşmamış erken embriyo kök hücrelerinin ve çeşitli yetişkin kök hücrelerinin gelişimi ve devamlılığının düzenlenmesinde rol oynayan bir transkripsiyon faktörüdür. Sox2, diğer pluripotensi faktörleri ...