Yazar "Turacli, Irem Dogan" için listeleme
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Effects of thiostrepton alone or in combination with selumetinib on triple-negative breast cancer metastasis
Korkmaz, Funda Demirtas; Turacli, Irem Dogan; Esendagli, Guldal; Ekmekci, Abdullah (Springer, 2022)Objective FoxM1 transcription factor contributes to tumor metastasis and poor prognosis in many cancers including triple-negative breast cancer (TNBC). In this study, we examined the effects of FoxM1 inhibitor Thiostrepton ... -
Flavopiridol's effects on metastasis in KRAS mutant lung adenocarcinoma cells
Turacli, Irem Dogan; Korkmaz, Funda Demirtas; Candar, Tuba; Ekmekci, Abdullah (Wiley, 2019)Background There is still no clinically approved agent for mutant KRAS, which is the most common alteration in non-small-cell lung cancer (NSCLC). Flavopiridol is a semisynthetic flavonoid that inhibits cell growth through ... -
Metformin resistant MDA-MB-468 cells exhibit EMT-like phenotype and increased migration capacity
Koker, Sahika Cingir; Yalcin, Banu; Turacli, Irem Dogan (Springer, 2022)Purpose Metformin is one of the most prescribed drugs for the treatment of type II diabetes. Its anti-proliferative effect is also taken advantage for the treatment of cancer. Despite many of the studies mentioning the ... -
Molecular Mechanisms in Formation and Progression of Malignant Melanoma
Turacli, Irem Dogan (Galenos Yayincilik, 2017)Malignant melanomas which arise from melanocytes are differentiated at the molecular level as well as cellular level which affects their therapeutic approach. Melanoma pathogenesis is managed by genetic factors. During its ... -
Role of metformin on base excision repair pathway in p53 wild-type H2009 and HepG2 cancer cells
Turacli, Irem Dogan; Candar, Tuba; Yuksel, Berrin Emine; Demirtas, Selda (Sage Publications Ltd, 2018)The antidiabetic agent metformin was shown to further possess chemopreventive and chemotherapeutic effects against cancer. Despite the advances, the underlying molecular mechanisms involved in decreasing tumor formation ...