Effects of glomerular filtration rate on the severity of coronary heart disease

Abstract

Objective: Chronic kidney disease (CKD) is considered to beone of the most common risk factors for cardiovascular diseases.Glomerular filtration rate (GFR) is the best method oftesting level of kidney function and determining stage of kidneydisease. The aim of this study was to examine the impactof renal function on severity of coronary heart disease (CHD).Methods: The present study included 918 patients undergoingelective coronary angiography. GFR was evaluated bysimplified Modification of Diet in Renal Disease (MDRD) formula(mL/min/1.73 m2). The extent and severity of CHD wereevaluated according to SYNTAX score.Results: According to SYNTAX score, 416 patients had normalcoronary arteries or nonsignificant CHD (control group),267 had mild CHD (SYNTAX score: 1–22), 129 had moderateCHD (SYNTAX score: 23–32), and 106 had severe CHD(SYNTAX score: ?33). Estimated GFR values (median [25th–75th percentiles]) were 99.00 (83.00–116.00) in the controlgroup, 85.00 (73.00–101.00) in the mild CHD group, 87.00(73.25–101.75) in the moderate CHD group, and 81.00(65.00–101.00) in the severe CHD group. According to Spearman’srank correlation analysis, a negative correlation foundbetween MDRD and SYNTAX score was statistically significant(p<0.001, r=-0.268).Conclusion: Renal function is an important predictor of presenceand severity of angiographic CHD in patients without severerenal impairment. Negative correlation between MDRDand SYNTAX score was determined. This simple biochemicaltest can be used in determining risk of cardiovascular diseaseaside from other risk factors during routine clinical practice.