Single dose of preoperative analgesia with gabapentin (600 mg) is safe and effective in monitored anesthesia care for nasal surgery
Künye
Kazak, Z., Meltem Mortimer, N., & Sekerci, S. (2009). Single dose of preoperative analgesia with gabapentin (600 mg) is safe and effective in monitored anesthesia care for nasal surgery. European Archives of Oto-Rhino-Laryngology, 267(5), 731–736. https://doi.org/10.1007/s00405-009-1175-5Özet
This study was aimed to compare the intraoperative
sedative and perioperative analgesic drug requirements
and the incidences of postoperative side effects on
the patients who received preoperative gabapentin or placebo.
Sixty patients undergoing nasal septal or nasal sinus
surgery were included. The patients received either 600 mg
gabapentin (Group G) or placebo (Group P) orally, 1 h
before surgery. The scores for sedation and pain were
recorded at 5, 15, 30, 45 and 60 min, intraoperatively and
at 30 min, 1, 2, 4, 6, 9, 12, 16, 20, 24 h, postoperatively.
Sedation was achieved with an IV bolus of propofol and
continuous infusion of remifentanil. There were significant
differences between gabapentin and placebo groups with
regard to total consumptions of remifentanil (171.42 ± 68
vs. 219.17 ± 95 lg, respectively; P = 0.033) and propofol
(59.45 ± 36.08 vs. 104.14 ± 54.98 mg, respectively;
P = 0.001). Group G patients had significantly lower
intraoperative VAS scores at all time points (P\0.05).
The anxiety score of Group G was better at all times
(P\0.05). All postoperative pain scores were lower in the
Group G (P\0.05). Time to first request for analgesic was
12.7 ± 2.3 h in Group G, and 7.8 2.1 h in Group P
(P\0.0001). Total consumption of lornoxicam was lower
in Group G (P\0.004). We concluded that monitored
anesthesia care combined with preoperative analgesia with
a low dose of (600 mg) oral gabapentin is an efficient
option with tolerable side effects for patients undergoing
ear, nose and throat ambulatory surgery.