The levels of matrix metalloproteinase-9 and neutrophil gelatinase-associated lipocalin in different stages of endometriosis
AuthorDurmuş, Arzu Bostancı
Cengiz, Sevim Dinçer
Gürsoy, Aslı Yarcı
Çağlar, Gamze Sinem
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CitationBostanci Durmus, A., et al. “The Levels of Matrix Metalloproteinase-9 and Neutrophil Gelatinase-Associated Lipocalin in Different Stages of Endometriosis.” Journal of Obstetrics and Gynaecology, 39(7), 991–995, pubmed.ncbi.nlm.nih.gov/31177884/, 10.1080/01443615.2019.1584889.
This study was designed to explore matrix metalloproteinase-9 (MMP-9), neutrophil gelatinase-associated lipocalin (NGAL) levels and MMP-9/NGAL ratio in women with and without endometriosis diagnosed surgically and/or histopathologically. The correlation between biomarkers and the severity of the disease is analysed. The revised American Fertility Society classification system was used to determine the severity of endometriosis. Serum MMP-9 and Ca125, urine NGAL levels were measured in all participants. Serum MMP-9 levels were significantly higher in the study group (n¼60) compared to controls (n¼31) (15.0 pg/mL (6.0–143.0) vs. 12.0 (4.0–18.0), respectively; p¼.002). MMP-9 levels were significantly higher in severe endometriosis compared to mild endometriosis subgroups (p<.001). No significant difference was found between NGAL levels in study and control groups (p>.05). The diagnostic value of MMP-9 and NGAL is not superior than CA-125 for endometriosis. Nevertheless, MMP-9 might be a potential predictive marker for advanced stage of the disease.