Do follicular fluid advanced glycation end products levels affect the ovarian response in unexplained infertility?

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2021Author
Seven, BanuTaşçı, Yasemin
Gülerman, Cavidan
Çandar, Tuba
Kokanalı, Kuntay
Yüksel, Yasemin
Bardakçı, Yesim
Engin-Üstün, Yaprak
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Seven, B., Tascı, Y., Gülerman, C., Candar, T., Kokanalı, K., Yüksel, Y., Bardakcı, Y., & Engin-Ustün, Y. (2021). Do follicular fluid advanced glycation end products levels affect the ovarian response in unexplained infertility? Gynecological Endocrinology, 37(9), 802–806. https://doi.org/10.1080/09513590.2021.1897095Abstract
Objective: To compare the advanced glycation end products (AGEs) levels in follicular fluid according to
the different ovarian responses of women who underwent controlled ovarian stimulation due to unexplained
infertility and to examine the relationship between these levels and pregnancy outcomes.
Methods: Sixty-three women who underwent fresh IVF/ICSI cycles with GNRH antagonist protocol were
divided into 3 groups according to the number of retrieved oocytes as suboptimal (4–9 oocytes), optimal
(10–15 oocytes) and high (>15 oocytes) responders. AGEs levels in follicular fluid were measured by
ELISA method.
Results: AGEs levels were 6.81 ± 2.20 mg/ml, 5.30 ± 2.01 and 6.44 ± 1.43 mg/ml in suboptimal, optimal and
high response group, respectively. AGEs level was significantly higher in suboptimal response group than
in optimal response group. The cutoff level of 6.19 mg/ml had a sensitivity of 59.3% and a specificity of
66.7% in distinguishing the suboptimal response group from the optimal response group. However, there
were no statistically significant difference between AGEs levels and clinical pregnancy and live birth rates.
Conclusion: Increased AGEs level in follicular fluid may be associated with decreased ovarian response
during controlled ovarian stimulation in unexplained infertility case, however, it does not provide information
about pregnancy outcomes.