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dc.contributor.authorÖztaş, Efser
dc.contributor.authorÇağlar, Gamze Sinem
dc.contributor.authorKaya, Cemil
dc.contributor.authorKaradağ, Demet
dc.contributor.authorDemirtaş, Selda
dc.contributor.authorKurt, Mevlüt
dc.contributor.authorPabuçcu, Recai
dc.date.accessioned2022-03-10T19:32:43Z
dc.date.available2022-03-10T19:32:43Z
dc.date.issued2014
dc.identifier.citationOztas, E., Caglar, G. S., Kaya, C., Karadag, D., Demirtas, S., Kurt, M., & Pabuccu, R. (2014). “Association of anti-Mullerian hormone and small-dense low-density lipoprotein cholesterol with hepatosteatosis in young lean women with and without polycystic ovary syndrome”. European Journal of Obstetrics & Gynecology and Reproductive Biology, 182, 240-246. https://doi.org/10.1016/j.ejogrb.2014.11.024
dc.identifier.issn0301-2115
dc.identifier.issn1872-7654
dc.identifier.urihttps://doi.org/10.1016/j.ejogrb.2014.11.024
dc.identifier.urihttps://hdl.handle.net/20.500.14065/3005
dc.description.abstractObjective: To study the association of anti-Mullerian hormone (AMH) and small-dense low-density lipoprotein cholesterol (sd-LDL) with hepatosteatosis among young, lean, polycystic ovary patients. Study design: A prospective, case control study was carried out including 79 young lean women. Fiftyeight women with polycystic ovary syndrome (PCOS) and 21 age-and BMI-matched healthy controls were recruited. Anthropometric variables, biochemical and hormonal parameters, insulin-resistance indices, lipid profiles including sd-LDL levels and serum AMH levels were determined. Hepatic lipid content was evaluated by abdominal ultrasonography (USG). Determining the best predictor(s) which discriminate normal USG and hepatosteatosis was analyzed by multiple logistic regression analyses. Adjusted odds ratios and 95% confidence intervals were also calculated. Results: PCOS patients had an increased prevalence of hepatosteatosis by 41.4% (P = 0.006) and they had significantly higher levels of sd-LDL and AMH when compared with the control group (P < 0.001). AMH and sd-LDL levels were positively and significantly associated with hepatosteatosis in young lean women with and without PCOS (OR: 2.877, 95%CI: 1.453–5.699, P: 0.02 and OR: 1.336, 95%CI: 1.083– 1.648, P: 0.007, respectively). AMH and sd-LDL levels were positively correlated in PCOS patients (r = 0.626, P < 0.001). Both sd-LDL and AMH levels were the most predictive parameters for the determination of hepatosteatosis within the PCOS group. (OR: 3.347, 95%CI: 1.348–8.313, P = 0.009 and OR: 1.375, 95%CI: 1.072–1.764, P = 0.012, respectively). Statistically significant higher levels of AMH were associated with hepatosteatosis both in insulin resistance (IR) positive and IR negative PCOS patients (P < 0.001). Conclusion: Hepatosteatosis is common in young lean PCOS patients. Increased AMH and sd-LDL levels may independently predict hepatosteatosis in young lean women with and without PCOSen_US
dc.language.isoengen_US
dc.publisherElsevier Science Bven_US
dc.relation.ispartofEuropean Journal of Obstetrics & Gynecology and Reproductive Biologyen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAnti-Mullerian hormone
dc.subjectHepatosteatosis
dc.subjectPolycystic ovary syndrome
dc.subjectSmall-dense low-density lipoprotein
dc.subjectCholesterol
dc.titleAssociation of anti-Mullerian hormone and small-dense low-density lipoprotein cholesterol with hepatosteatosis in young lean women with and without polycystic ovary syndromeen_US
dc.typecorrectionen_US
dc.authoridÖztaş, Efser / 0000-0001-9187-4632
dc.authoridÇağlar, Gamze Sinem / 0000-0003-1956-0908
dc.authoridDemirtaş, Selda / 0000-0001-7700-9917
dc.authoridPabuçcu, Recai / 0000-0003-4563-3592
dc.authoridKaya, Cemil
dc.authoridKaradağ, Demet
dc.departmentTıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Kadın Hastalıkları ve Doğumen_US
dc.departmentTıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya
dc.departmentTıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Radyoloji
dc.institutionauthorÖztaş, Efser
dc.institutionauthorÇağlar, Gamze Sinem
dc.institutionauthorKaya, Cemil
dc.institutionauthorKaradağ, Demet
dc.institutionauthorDemirtaş, Selda
dc.institutionauthorPabuçcu, Recai
dc.identifier.doi10.1016/j.ejogrb.2014.11.024
dc.identifier.volume182en_US
dc.identifier.startpage240en_US
dc.identifier.endpage246en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.wosqualityQ3
dc.identifier.wosWOS:000347861500045en_US
dc.identifier.pmid25632416en_US


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