dc.contributor.author | Gunay, Oyusuf | |
dc.contributor.author | Tutuncu, Tanju | |
dc.contributor.author | Ocalan, Tuba | |
dc.contributor.author | Bilgihan, Ayse | |
dc.contributor.author | Korkmaz, Gulcan | |
dc.contributor.author | Kama, Nuri Aydin | |
dc.date.accessioned | 2022-03-10T19:37:14Z | |
dc.date.available | 2022-03-10T19:37:14Z | |
dc.date.issued | 2019 | |
dc.identifier.issn | 1302-0072 | |
dc.identifier.issn | 2147-2688 | |
dc.identifier.uri | https://doi.org/10.4274/haseki.galenos.2019.4752 | |
dc.identifier.uri | https://hdl.handle.net/20.500.14065/3243 | |
dc.description.abstract | Aim: The etiopathogenesis of gallstone formation is well known, but only a few studies have investigated the effects of thyrotoxicosis on gallstone formation. In this study, we investigated the contribution of thyrotoxicosis to gallstone formation in rabbits. Methods: Forty-four New Zealand rabbits were used. The rabbits were divided into six groups, with each group receiving a different diet. At the end of seven weeks, all rabbits were sacrificed, blood was collected for analysis, and cholecystectomy was performed. Results: Serum levels of both free triiodothyronine (FT3) and thyroxine (FT4) were significantly higher in rabbits receiving thyroid hormone (p<0.001). The bile cholesterol saturation index (CSI) in the group receiving only thyroxine hormone was statistically higher than in the control group (p=0.014). The rabbit group receiving a lithogenic diet and thyroxine hormone had significantly higher myeloperoxidase activities and fibrinogen levels, but lower bile acid levels compared to controls (p<0.001). Focal leukocyte infiltration was noted in rabbits receiving thyroxine hormone, but no significant differences were found in bile calcium levels between the groups (p>0.05). Conclusions: Thyrotoxicosis promotes an increase in gallstone formation risk as a result of an increased bile CSI and gallbladder mucosal inflammation. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Galenos Yayincilik | en_US |
dc.relation.ispartof | Haseki Tip Bulteni-Medical Bulletin of Haseki | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Cholelithiasis | en_US |
dc.subject | thyrotoxicosis | en_US |
dc.subject | gallstone | en_US |
dc.subject | hyperthyroidism | en_US |
dc.subject | cholesterol | en_US |
dc.subject | Thyroid-Hormone | en_US |
dc.subject | Bile-Acids | en_US |
dc.subject | Cholesterol | en_US |
dc.subject | Disease | en_US |
dc.subject | Dysfunction | en_US |
dc.subject | Secretion | en_US |
dc.title | Assessment of Effects of Thyrotoxicosis on Gallstone Formation in Rabbits | en_US |
dc.type | article | en_US |
dc.authorid | Bilgihan, Ayse / 0000-0003-1307-2794 | |
dc.authorid | korkmaz, gulcan guntas/0000-0002-3638-4662 | |
dc.department | Ufuk Üniversitesi | en_US |
dc.identifier.doi | 10.4274/haseki.galenos.2019.4752 | |
dc.identifier.volume | 57 | en_US |
dc.identifier.issue | 1 | en_US |
dc.identifier.startpage | 91 | en_US |
dc.identifier.endpage | 97 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.authorwosid | Bilgihan, Ayse/AAH-9815-2021 | |
dc.authorwosid | korkmaz, gulcan guntas/B-9262-2014 | |
dc.authorscopusid | 54580847100 | |
dc.authorscopusid | 8631139100 | |
dc.authorscopusid | 57208280055 | |
dc.authorscopusid | 7003758848 | |
dc.authorscopusid | 55366092800 | |
dc.authorscopusid | 7004008572 | |
dc.identifier.wos | WOS:000461743400017 | en_US |
dc.identifier.scopus | 2-s2.0-85064340209 | en_US |