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dc.contributor.authorBeriat, G.K.
dc.contributor.authorYalçinkaya, E.
dc.contributor.authorAkmansu, S.H.
dc.contributor.authorAlhan, A.
dc.contributor.authorErdo?an, F.G.
dc.contributor.authorTu?rul, B.
dc.date.accessioned2022-03-10T19:38:46Z
dc.date.available2022-03-10T19:38:46Z
dc.date.issued2011
dc.identifier.issn13007475
dc.identifier.urihttps://doi.org/10.5606/kbbihtisas.2011.036
dc.identifier.urihttps://hdl.handle.net/20.500.14065/3473
dc.description.abstractThis study aims to evaluate the clinical effects of isotretinoin (13-cis-retinoic acid), a derivative of retinoic acid, on the clinical features of chronic rhinosinusitis. The study group included 25 chronic rhinosinusitis patients (16 females, 9 males; mean age 25.2 ± 6.8 years; range 15 to 25 years) who were on isotretinoin for acne treatment, while the control group consisted of 25 chronic rhinosinusitis patients (15 females, 10 males; mean age 25.2 ± 6.8 years; range 15 to 25 years) who were not on isotretinoin treatment. The patients' symptom scores in visual analog scale (VAS), Lanza and Kennedy nasal endoscopic scores and Newman computed tomography (CT) scores were obtained in order to evaluate the their symptom, examination and radiological findings. These patients' symptom and examination results were evaluated first day, week two and at months 3-5 and 6-10. Paranasal sinus CT results were studied first day and at months 6-10. In the group of patients being administered isotretinoin, no significant change in the mean symptom and examination scores was detected during the acute phase (week 2), while there was a significant regression in the long-term (months 3-5 and 6-10). There was a significant regression in the mean CT score after isotretinoin therapy. In the control group no significant change was seen in any of the scores. The number of acute sinusitis attacks were significantly lower in the isotretinoin group than in the control group. No significant difference was found between the two groups in terms of the duration of the healing period of acute sinusitis attacks. We conclude that the long-term administration of isotretinoin has positive effects on the clinical results of chronic rhinosinusitis.en_US
dc.language.isoengen_US
dc.relation.ispartofKulak burun bo?az ihtisas dergisi : KBB = Journal of ear, nose, and throaten_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectdermatological agenten_US
dc.subjectisotretinoinen_US
dc.subjectacne vulgarisen_US
dc.subjectadolescenten_US
dc.subjectadulten_US
dc.subjectarticleen_US
dc.subjectcase control studyen_US
dc.subjectchronic diseaseen_US
dc.subjectcomputer assisted tomographyen_US
dc.subjectevaluationen_US
dc.subjectfemaleen_US
dc.subjecthumanen_US
dc.subjectintradermal drug administrationen_US
dc.subjectmaleen_US
dc.subjectmiddle ageden_US
dc.subjectpain assessmenten_US
dc.subjectpathologyen_US
dc.subjectradiographyen_US
dc.subjectrhinitisen_US
dc.subjectsinusitisen_US
dc.subjecttreatment outcomeen_US
dc.subjectTurkey (republic)en_US
dc.subjectAcne Vulgarisen_US
dc.subjectAdministration, Cutaneousen_US
dc.subjectAdolescenten_US
dc.subjectAdulten_US
dc.subjectCase-Control Studiesen_US
dc.subjectChronic Diseaseen_US
dc.subjectDermatologic Agentsen_US
dc.subjectFemaleen_US
dc.subjectHumansen_US
dc.subjectIsotretinoinen_US
dc.subjectMaleen_US
dc.subjectMiddle Ageden_US
dc.subjectPain Measurementen_US
dc.subjectRhinitisen_US
dc.subjectSinusitisen_US
dc.subjectTomography, X-Ray Computeden_US
dc.subjectTreatment Outcomeen_US
dc.subjectTurkeyen_US
dc.titleEvaluation of the clinical effects of isotretinoin on chronic rhinosinusitis.en_US
dc.typearticleen_US
dc.departmentUfuk Üniversitesien_US
dc.identifier.doi10.5606/kbbihtisas.2011.036
dc.identifier.volume21en_US
dc.identifier.issue5en_US
dc.identifier.startpage251en_US
dc.identifier.endpage256en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.authorscopusid36522196500
dc.authorscopusid54796346800
dc.authorscopusid36698656500
dc.authorscopusid37005509100
dc.authorscopusid15052990700
dc.authorscopusid57191858450
dc.identifier.scopus2-s2.0-84555178688en_US
dc.identifier.pmid21919829en_US


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