Succesfull Management of Pregnancy Complicated with Congenital AT-3 Deficiency

Abstract

Antithrombin-3 (AT-3) is a natural anticoagulant that inhibits thrombin, activated factor X and other serine proteases in the coagulation cascade, and its activity accelerated more than 1000-fold by heparin binding. Congenital AT-3 deficiency is inherited as an autosomal dominant trait and affects less than 0.2% of the general population.1 This deficiency is considered to be a high-risk thromboembolic condition, with an odds ratio venous thromboembolism (VTE) of 16.3 compared with individuals with a nonthrombophilic status.1 In this case report, succesfull management and delivery of a congenital AT-3 deficient pregnant woman was extensively discussed along with the lşterature findinds.