Evaluation of Oxidative Stress Marker and Ischemia Modified Albumin Levels in Patients with Psoriasis Vulgaris

Abstract

Objective: As a systemic inflammatory skin disease, psoriasis vulgaris (PS) is associated with cellular immune mechanisms. We aimed to evaluate oxidative stress markers and ischemia modified albumin levels in patients with PS and controls.Materials and Methods: The participants (over age of 18) who applied to the dermatology outpatient clinic between September 2020 - May 2021 and diagnosed with PS (n=50) were enrolled into the study. Oxidative stress markers such as nitric oxide (NO), malondialdehyde (MDA), 8-hydroxy 2-deoxy guanosine (8-OHdG), superoxide dismutase (SOD), glutathione peroxidase (GPx) parameters and ischemia modified albumin (IMA) levels in patients with PS and controls were evaluated.Results: A total of 100 volunteers, 50 with PS and 50 healthy controls were enrolled in the study. In the measurements of oxidative stress markers, GPX, 8-OHdG, MDA, IMA, IMA/Albumin and NO parameters were found to be statistically as significant between the patient and control groups. Also, SOD, 8-OHdG, IMA and NO were found to be statistically as significant between two psoriasis severity index (PASI) groups.Conclusion: Elevated levels of 8-OHdG, MDA, IMA, IMA/Albumin, NO and decreased levels of GPx were observed in patients with PS. To clarify this topic, further and comprehensive studies are needed.