Evaluation of the Prognostic Role of the Systemic Immune Inflammation Index in Postmenopausal Osteoporosis

Abstract

Objective: The aim of this study is to evaluate the prognos tic role of the systemic immune inflammation index (SII) in postmenopau sal osteoporosis and to examine the SII, neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), mean platelet volume (MPV), erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), femur and lumbar bone mineral densitometry (BMD) T scores and their relationships with each other. Material and Methods: 139 patients were included in this retros pective case-control study. Lumbar vertebra 1-4 and femoral neck BMD T scores, ages, ESR, CRP, MPV values were recorded. NLR, PLR, and SII values were calculated. Patients with lumbar and femoral T scores ?-1 were the control group (n=31); with lumbar or femoral T scores between -1 and -2.5 were the osteopenia group (n=38), ?-2.5 were the osteoporosis group (n=37), ?-2.5 and one or more fragility fractures were the severe osteopo rosis group (n=33). Results: SII value was significantly higher in the os teoporosis group compared to the osteopenia group (p=0.004). SII value had a diagnostic value in predicting osteoporosis in patients with osteopenia (area under curve: 0.686, %95 confidence interval: 0.565-0.806, p<0.006); the cut-off value for the SII was calculated as 458.46. ESR value was sig nificantly higher in the severe osteoporosis group compared to the osteope nia group and the control group (p<0.001, p=0.0080). There was no significant difference between the groups in terms of other variables (p>0.05). Conclusion: SII value can be a prognostic predictor that can be used to predict the development of osteoporosis in postmenopausal osteo penic patients.