Association Between Insulin Resistance Estimated by Triglyceride Glucose Index and In-Stent Restenosis in Non-Diabetic Patients

Abstract

Objectives: The triglyceride glucose index (TGI) is associated with poor prognosis in cardiovascular disease. The usefulness of TGI to predict coronary in-stent restenosis (ISR) has not been determined. This study aimed to investigate the relationship between TGI and ISR in patients with stable coronary artery disease (CAD) undergoing angiography. Materials and Methods: This retrospective study analyzed the data of 224 non-diabetic patients with coronary drugeluting stents and undergoing angiography. The patients were divided into two groups based on the angiogram results: the non-ISR group (n=114) and the ISR group (n=100). TGI was compared between the two groups. The clinical characteristics and laboratory data were considered for univariate and multivariate analyses. Results: No significant differences in age, sex, hypertension, and smoking history were found between the ISR and nonISR groups. TGI was higher in the ISR group than in the non-ISR group (p=0.011). According to the multiple logistic regression analysis, Gensini score and SYNTAX score, TGI and white blood cell count were independent predictors of ISR. Conclusion: Patients with ISR were found to have higher TGI than those without ISR, suggesting that TGI might be a valuable predictor of ISR in patients with stable CAD.