Evaluation of pro-atherogenic lipid profile and high atherohenic indexes in patients with Behcet's disease: A case-control study
Özet
BackgroundBehcet's disease is a systemic auto-immune and auto-inflammatory chronic disease in which genetic and environmental factors play a role. Patients with Behcet's are at significant risk for developing many comorbidities, including cardiovascular diseases. AimsIt was aimed to investigate the relationship between serum lipid parameters and atherogenic indexes to evaluate the cardiovascular risk status in patients with Behcet's disease. Patients/MethodsThis study was designed as a single-center, retrospective case-control study. The study was conducted with 212 patients over 18 years of age, 106 in the case group and 106 in the control group. ResultsThere was a significant difference in lipid values between the patients with Behcet's disease and the control group. While the serum triglyceride, total cholesterol, low-density lipoprotein cholesterol (LDL-C), and non-high-density lipoprotein cholesterol (NHC) levels were significantly higher, the high-density lipoprotein cholesterol (HDL-C) level was low in patients with Behcet's disease. From atherogenic indexes, Atherogenic Index of Plasma (AIP) (0.03 +/- 0.27 vs. -0.07 +/- 0.23, p = 0.003), Castelli Risk Index I (CRI-I) (4.24 +/- 1.07 vs. 3.02 +/- 0.96, p < 0.001), Castelli Risk Index II (CRI-II) (2.65 +/- 0.81 vs. 1.84 +/- 0.59, p < 0.001) and Atherogenic Coefficient (AC) (3.24 +/- 1.07 vs. 2.02 +/- 0.96, p < 0.001) levels were significantly higher in patients with Behcet's disease. ConclusionOur study shows that patients with Behcet's have a higher pro-atherogenic lipid profile and atherogenic indexes at high risk. Patients with Behcet's have an increased risk of cardiovascular diseases associated with atherosclerosis.