dc.contributor.author | Aribas, Yavuz Kemal | |
dc.contributor.author | Aribas, Atike Burcin Tefon | |
dc.contributor.author | Ercin, Ugur | |
dc.contributor.author | Sarikaya, Burcu | |
dc.contributor.author | Bilgihan, Ayse | |
dc.contributor.author | Bilgihan, Kamil | |
dc.date.accessioned | 2023-11-16T18:30:24Z | |
dc.date.available | 2023-11-16T18:30:24Z | |
dc.date.issued | 2022 | |
dc.identifier.issn | 1081-597X | |
dc.identifier.issn | 1938-2391 | |
dc.identifier.uri | https://doi.org/10.3928/1081597X-20220906-01 | |
dc.identifier.uri | https://hdl.handle.net/20.500.14065/5649 | |
dc.description.abstract | PURPOSE: To evaluate the biomechanical changes and ad-vanced oxidation protein products (AOPP) production after different corneal cross-linking (CXL) protocols with or with-out oxygen supplementation.METHODS: Ovine eyes in the study were equally distributed to five groups as control, standard Dresden protocol, diluted alco- hol-and iontophoresis-assisted CXL (DAI-CXL), and 0.1% and 0.2% riboflavin-mediated iontophoresis-assisted CXL with oxy-gen supplementation (I-CXL). Corneas that received CXL were divided into two equal parts, one part was used for uniaxial tensiometry and one part was used for AOPP measurement.RESULTS: All treatment groups showed higher Young's modu-lus and stiffness compared to the control group (P < .05). Both oxygen-assisted I-CXL groups with 0.1% and 0.2% riboflavin con-centrations had higher corneal Young's modulus (P = .009 and .006, respectively) and stiffness (P = .009) values, whereas the DAI-CXL group had lesser Young's modulus and stiffness values (P = .032) compared to the Dresden protocol group. All treatment groups showed higher AOPP concentrations compared to the control group (P < .05). DAI-CXL and I-CXL groups showed similar AOPP formation compared to the Dresden protocol (P = .673).CONCLUSIONS: When the epithelium is intact, the desired in-crease in corneal stiffness might not be achieved. However, increasing the oxygen in the environment might provide a suf-ficient increase in stiffness in cases undergoing epithelium-on I-CXL, which might be promising in terms of shortening the CXL therapy and decreasing the complications. | en_US |
dc.description.sponsorship | OENTAL (Teacher Naime Toemek Research Laboratory); Hacettepe University Bioengineering Department | en_US |
dc.description.sponsorship | The authors thank Naime Toemek, who is the supporter of the OENTAL (Teacher Naime Toemek Research Laboratory) and the Hacettepe University Bioengineering Department. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Slack Inc | en_US |
dc.relation.ispartof | Journal of Refractive Surgery | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Transepithelial Diluted Alcohol | en_US |
dc.subject | Biomechanical Properties | en_US |
dc.subject | Riboflavin Concentration | en_US |
dc.subject | Progressive Keratoconus | en_US |
dc.subject | Porcine Corneas | en_US |
dc.subject | Epithelium | en_US |
dc.subject | Efficacy | en_US |
dc.subject | Stress | en_US |
dc.subject | Light | en_US |
dc.title | Iontophoresis Corneal Cross-linking With Oxygen Supplementation in Ovine Eyes | en_US |
dc.type | article | en_US |
dc.authorid | Arıbaş, Yavuz Kemal/0000-0001-5516-0747 | |
dc.department | Ufuk Üniversitesi | en_US |
dc.identifier.doi | 10.3928/1081597X-20220906-01 | |
dc.identifier.volume | 38 | en_US |
dc.identifier.issue | 10 | en_US |
dc.identifier.startpage | 674 | en_US |
dc.identifier.endpage | 681 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.authorwosid | Arıbaş, Yavuz Kemal/HPC-5846-2023 | |
dc.identifier.wos | WOS:000875668400001 | en_US |
dc.identifier.scopus | 2-s2.0-85139428467 | en_US |
dc.identifier.pmid | 36214347 | en_US |