Browsing by Author "Doğan Turaçlı, İrem"
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The comparison between dual inhibition of mTOR with MAPK and PI3K signaling pathways in KRAS mutant NSCLC cell lines
KRAS mutations are found in 15–25 % of patients with lung adenocarcinoma, and they lead to constitutive activation of KRAS signaling pathway that results in sustained cell proliferation. Currently, there are no direct ... -
A new synthetic approach for pyrazolo[1,5-a]pyrazine-4(5H)-one derivatives and their antiproliferative effects on lung adenocarcinoma cell line
Starting from the 3,5-dimethyl pyrazole ring and acetophenone derivatives, five different N-propargylated C-3 substitutedpyrazoles were obtained. These derivatives were reacted with different amine derivatives using Cs2CO3in ... -
The outcomes of an impaired powerhouse in KRAS mutant lung adenocarcinoma cells by Elesclomol
Objectives: Lung cancer stands out as the most common cancer type worldwide. The most common genetic alteration detected in adenocarcinoma patients is KRAS. KRAS mutated patients still cannot get benefit from precision ... -
Potential effects of metformin in DNA BER system based on oxidative status in type 2 diabetes
Doğan Turaçlı, İrem; Çandar, Tuba; Yüksel, Emine Berrin; Kalay, Şebnem; Oğuz, Ali Kemal; Demirtaş, Selda (2018)Metformin is used to reduce hyperglycemia that induces energetic stress and leads to reduction in gluconeogenesis. Also, metformin inhibits complex I in oxidative phosphorylation, thereby decreasing cellular ATP levels. ...
