Anti-Mullerian hormone and insulin resistance in classic phenotype lean PCOS
Citation
Caglar, G. S., Kahyaoglu, I., Pabuccu, R., Demirtas, S., & Seker, R. (2013). Anti-Mullerian hormone and insulin resistance in classic phenotype lean PCOS. Archives of Gynecology and Obstetrics, 288(4), 905–910. https://doi.org/10.1007/s00404-013-2833-9Abstract
Purpose This study is designed to explore the correlation
between AMH levels and IR in normal weight PCOS
women.
Materials and methods This prospective study was conducted
on 55 patients, who were admitted to obstetrics and
gynecology department of a university clinic. Study group
was consisted of 34 patients diagnosed as polycystic ovary
syndrome (PCOS) according to the Rotterdam Criteria,
whereas control group was consisted of 21 healthy volunteers
without any features of clinical or biochemical hyperandrogenism,
who had regular menstrual cycles. BMI C 25 kg/m2
were considered overweight and obese and excluded. Blood
samples were obtained during days 2–3 after spontaneous
menses or progesterone-induced withdrawal bleeding after
overnight fasting for at least 12 h. The weight, height, hip and
waist circumferences of the patients were measured. Fasting
insulin and glucose (FPG) levels were used for calculating
different insulin resistance indexes (Homeostatic Model
Assessment (HOMA-IR), Quantitative Insulin Sensitivity
Check Index (QUICKI)).
Results No significant difference was found between
PCOS and control groups regarding the mean age, BMI,
waist to hip ratio (WHR), mean values of FPG, FPG/insulin
ratio and HOMA B (p[0.05). AMH values were significantly
higher in PCOS cases when compared with controls
(4.7 vs. 3.4 ng/mL) (p\0.05).The mean values of HOMAIR
and QUICKI indexes were significantly higher among
PCOS cases when compared with controls. E2 levels were
significantly lower and Total-T were significantly higher in
PCOS patients. When PCOS cases are categorized according
to the existence of IR, no difference in Total-T and AMH
levels between both groups. Although not statistically significant,
a negative correlation of AMH with HOMA-IR and
a positive correlation with QUICKI index were found.
Among the hormone parameters, AMH was found to be
positively correlated with Total-T (r = 0.332, p = 0.013).
Conclusion Although the relation between AMH and
androgen production is supported by current evidence, the
mechanism underlying the relation between AMH and
insulin resistance is not clear yet.