The predictive role of serum cystatin C levels in polycystic ovary syndrome in adolescents
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[Belirlenecek]Date
2016Author
Çınar, MehmetAksoy, Rıfat Taner
Güzel, Ali İrfan
Tokmak, Aytekin
Çandar, Tuğba
Taşçı, Yasemin
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Show full item recordAbstract
Study Objective: To evaluate the correlation between serum cystatin levels and clinical parameters in adolescents with polycystic ovary
syndrome (PCOS).
Design, Setting, Participants, Interventions, and Main Outcome Measures: This prospective case-control study included 89 adolescents with
PCOS. Demographic characteristics and hormonal and biochemical parameters were compared between study (89 patients with PCOS) and
control (84 subjects without PCOS) groups. Risk factors recorded were age, body mass index (BMI), waist to hip ratio (WHR), FerrimaneGallwey
score, triglyceride, total cholesterol, high-density lipoprotein, low-density lipoprotein (LDL), high-sensitivity C-reactive
protein, cystatin C, follicle stimulating hormone, luteinizing hormone, estradiol, dehydroepiandrosterone sulfate, homeostatic model
assessment insulin resistance index, free testosterone, and progesterone levels.
Results: BMI, WHR, FerrimaneGallwey score, and triglyceride, LDL, total cholesterol, estradiol, dehydroepiandrosterone sulfate, free
testosterone, luteinizing hormone, high-sensitivity C-reactive protein, and cystatin C levels, and homeostatic model assessment insulin
resistance index scores were significantly higher, and high-density lipoprotein levels were lower in the PCOS patients compared with
healthy subjects (P ! .05). We also found positive correlations between the cystatin C levels and BMI, WHR, estradiol, high-sensitivity Creactive
protein, and LDL levels in the study group.
Conclusion: The serum cystatin C level is a promising marker for diagnosing adolescent patients with PCOS and suggests an inflammatory
etiology for these patients. Further studies with more participants should examine this potential association with inflammation.