Association of total serum antioxidant capacity with the Tei index in echocardiography in patients with microvascular angina

Abstract

Objectives Cardiac syndrome X (CSX) is a conditioncharacterized by exercise-induced chest pain that occursconsidering a normal coronary angiogram. We aimed toinvestigate the total serum antioxidant capacity (TAC) andbiventricular global functions using echocardiography inpatients with CSX.Patients and methods The study population included 55patients with typical anginal symptoms and a positiveexercise stress test, or ischemia in myocardial perfusionscintigraphy and normal coronary arteries detectedangiographically, and 49 healthy volunteers with atypicalchest pain and a negative stress test. TAC was assessedfrom blood samples. Transthoracic echocardiography wasperformed for the entire study population. The Tei index wascalculated using the formula IVCT+IVRT/ET.Results TAC was found to be significantly lower in the CSXgroup compared with the control group (0.70 ± 0.37 vs.1.5± 0.30, respectively, P<0.001). The Tei index wassignificantly higher in patients with CSX than the controlgroup (0.60± 0.18 vs. 0.42± 0.12, respectively, P<0.001).There was a significant and inverse relationship betweenTAC and the Tei index (r=-0.41, P<0.001). When wedivided the study population according to the normal range of TAC into the decreased TAC group (<1.30 mmol/l), thenormal TAC group (1.30–1.77 mmol/l), and the increasedTAC group (>1.77 mmol/l), it was found that the Tei indexwas higher in the decreased TAC group compared with theother groups (0.66 ± 0.18 vs. 0.49 ± 0.10 and0.46± 0.13 mmol/l, P<0.001, respectively).Conclusion Our study suggested that TAC wassignificantly decreased in CSX patients and decreasedantioxidant levels were related to impaired Tei index inechocardiography in patients with microvascularangina. Coron Artery Dis 26:620–625 Copyright © 2015Wolters Kluwer Health, Inc. All rights reserved.