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dc.contributor.authorErkan, Gülbanu
dc.contributor.authorYılmaz, Güldal
dc.contributor.authorCengiz, Mustafa
dc.contributor.authorDeğertekin, Ceyla Konca
dc.contributor.authorAkyol, Gülen
dc.contributor.authorÖzenirler, Seren
dc.date.accessioned2019-02-28T18:14:13Z
dc.date.available2019-02-28T18:14:13Z
dc.date.issued2013-08-07
dc.identifier.issn0344-0338
dc.identifier.urihttps://hdl.handle.net/20.500.14065/1362
dc.description.abstractEstrogens exert a protective effect against hepatic steatosis and fibrosis. Loss of estrogen receptor-alpha(ER- ) in the liver is associated with hepatic steatosis and inflammation in animal models. We conducteda study in order to investigate the presence and extent of ER- expression in HCV infection,and its relationship with histological and biochemical findings. Ninety biopsy-proven chronic hepatitis C(CHC) patients were enrolled in the study. Liver biopsy specimens were immunohistochemically stainedfor ER- expression. Nuclear ER- expression percentage was calculated. ER- was positive in 69 of thepatients (76%). ER- positive and negative groups were not significantly different in terms of age, gender,necroinflammatory activity, fibrosis, steatosis, serum levels of AST, ALT, ALP, GGT, and bilirubin. ER- expression percentage was not correlated with fibrosis, steatosis, necroinflammatory activity and biochemicalfindings. Although estrogens are known to be protective against fibrosis and steatosis in animalmodels, we did not find any significant correlation between ER- expression and histopathological andbiochemical findings in CHC patients. These findings should be verified in further large scale studies.en_US
dc.language.isoengen_US
dc.relation.ispartofseriesPathology – Research and Practice (209);727– 730
dc.rights[Belirlenecek]en_US
dc.subjectEstrogen receptor-alpha Chronic hepatitis Cen_US
dc.titleLack of association of hepatic estrogen receptor-alpha expression with histopathological and biochemical findings in chronic hepatitis Cen_US
dc.typeotheren_US
dc.departmentTıp Fakültesien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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