25-Hydroxy vitamin d levels and endothelial vasodilator function in normotensive women
Cicero, Arrigo Francesco
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Introduction: Vitamin D was shown to be related to endothelial function and bloodpressure. Reactive hyperaemia index (RHI) measurement by pulse arterial tonometryis a new method to evaluate vasodilator function of endothelium. We aimedto evaluate the relationship between vitamin D levels and RHI in women.Material and methods: We enrolled 56 normotensive, nonsmoker, normolipidemicand normoglycemic women, (23 with 25-OH-vita min D levels > 20 µg/l,and 33 with values lower than 20 µg/l). The cardiologist who was blind for vitaminD results executed measurements by pulse arterial tonometry. The measurementwas performed on the lying patient with pre- and post-occlusion measurementsof RHI by digital sensors placed on each index finger, by 5 minintervals. Pulse amplitudes were recorded, pre-occlusion and post-occlusionratio was compared by the software of device. Stepwise linear regression andmultiple regression analyses were performed to evaluate predictors of endothelialfunction.Results: The low vitamin D group had a lower RHI value than the normal vitaminD group (p = 0.042). In regression analysis, positive predictors of RHI wereserum 25-OHD (ß = 0.401; 95% CI 0.010-0.042, p = 0.002), serum albumin(ß = 0.315; 95% CI 0.286-2.350, p = 0.013), and, inversely, serum calcium(ß = –0.247; 95% CI (–1.347)-(–0.010), p = 0.047).Conclusions: Serum 25-hydroxy vitamin D was significantly related to endothelialfunctions measured as RHI, even in healthy non-smoker women.