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dc.contributor.authorKaya, Cemil
dc.contributor.authorPabuçcu, Recai
dc.contributor.authorBerker, Bülent
dc.contributor.authorSatıroğlu, Hakan
dc.date.accessioned2019-03-16T18:33:12Z
dc.date.available2019-03-16T18:33:12Z
dc.date.issued2009
dc.identifier.citationKaya, C., Pabuccu, R., Berker, B., & Satıroglu, H. (2010). Plasma interleukin-18 levels are increased in the polycystic ovary syndrome: relationship of carotid intima-media wall thickness and cardiovascular risk factors. Fertility and Sterility, 93(4), 1200–1207. https://doi.org/10.1016/j.fertnstert.2008.10.070
dc.identifier.issn0015-0282
dc.identifier.urihttps://hdl.handle.net/20.500.14065/1801
dc.identifier.urihttps://doi.org/10.1016/j.fertnstert.2008.10.070
dc.description.abstractObjective: To determine serum interleukin (IL)-18 levels and to find out whether IL-18 is associated with carotidintima-media wall thickness (IMT) and various cardiovascular risk factors in women with polycystic ovary syndrome(PCOS).Design: A prospective, controlled study.Setting: University hospital.Patient(s): Sixty women with PCOS and 60 healthy women were included this study.Intervention(s): Serum levels IL-18, homocysteine (Hcy), C-reactive protein (CRP), IL-6, malonyldialdehyde(MDA), lipid and hormone profiles were measured. Carotid IMT was evaluated for both common carotid arteries.Main Outcome Measure(s): Serum IL-18, carotid IMT, Hcy, CRP, IL-6,MDA, and homeostasis model assessmentof insulin resistance.Result(s): The evaluation, which was made without the obesity influence taken into consideration, revealedthat patients with PCOS have increased serum IL-18 levels than that of the control group (214 102 vs. 170 78 pg/mL). The interaction between PCOS and obesity was seen to have statistical significance (F ¼ 67.8).Body mass index (BMI), waist to-hip ratio, Hcy, and homeostasis model assessment of insulin resistance are independentdeterminants of plasma IL-18 in patients with PCOS. Elevated serum IL-18 levels were positivelyand significantly correlated with a greater carotid IMT. For Hcy and carotid IMT, the interaction betweenPCOS and obesity was found in a two-way ANOVA variation analysis (F ¼ 48.5 and F ¼ 81.5, respectively).Conclusion(s): Elevated serum IL-18 levels were associated with cardiovascular risk factors and carotid IMT inpatients with PCOS.en_US
dc.language.isoengen_US
dc.relation.ispartofFertility and Sterility
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectPCOSen_US
dc.subjectIL-18en_US
dc.subjectIL-6en_US
dc.subjectBMIen_US
dc.subjectInsulin resistanceen_US
dc.subjectHcyen_US
dc.subjectMDAen_US
dc.subjectCarotid IMTen_US
dc.titlePlasma interleukin-18 levels are increased in the polycystic ovary syndrome: relationship of carotid intima-media wall thickness and cardiovascular risk factorsen_US
dc.typeotheren_US
dc.authoridPabuçcu, Recai / 0000-0003-4563-3592
dc.departmentTıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Kadın Hastalıkları ve Doğumen_US
dc.institutionauthorKaya, Cemil
dc.institutionauthorPabuçcu, Recai
dc.identifier.doi10.1016/j.fertnstert.2008.10.070
dc.identifier.volume93
dc.identifier.issue4
dc.identifier.startpage1200
dc.identifier.endpage1207
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.authorscopusid18635130700
dc.authorscopusid22938037100
dc.identifier.wosqualityQ1
dc.identifier.wosWOS:000275541000025
dc.identifier.scopus2-s2.0-77049125944
dc.identifier.pmid19131059


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