The levels of matrix metalloproteinase-9 and neutrophil gelatinase-associated lipocalin in different stages of endometriosis
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[Belirlenecek]Date
2019-06-10Author
Durmuş, Arzu BostancıCengiz, Sevim Dinçer
Yılmaz, Hakan
Çandar, Tuba
Gürsoy, Aslı Yarcı
Çağlar, Gamze Sinem
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This study was designed to explore matrix metalloproteinase-9 (MMP-9), neutrophil gelatinase-associated
lipocalin (NGAL) levels and MMP-9/NGAL ratio in women with and without endometriosis diagnosed
surgically and/or histopathologically. The correlation between biomarkers and the severity of the
disease is analysed. The revised American Fertility Society classification system was used to determine
the severity of endometriosis. Serum MMP-9 and Ca125, urine NGAL levels were measured in all participants.
Serum MMP-9 levels were significantly higher in the study group (n¼60) compared to controls
(n¼31) (15.0 pg/mL (6.0–143.0) vs. 12.0 (4.0–18.0), respectively; p¼.002). MMP-9 levels were significantly
higher in severe endometriosis compared to mild endometriosis subgroups (p<.001). No significant difference
was found between NGAL levels in study and control groups (p>.05). The diagnostic value of
MMP-9 and NGAL is not superior than CA-125 for endometriosis. Nevertheless, MMP-9 might be a
potential predictive marker for advanced stage of the disease.