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dc.contributor.authorPabuçcu, Emre Göksan
dc.contributor.authorÇağlar, Gamze Sinem
dc.contributor.authorPabuçcu, Recai
dc.date.accessioned2022-03-10T19:29:25Z
dc.date.available2022-03-10T19:29:25Z
dc.date.issued2015
dc.identifier.citationPabuccu, E. G., Caglar, G. S., & Pabuccu, R. (2015). Estrogen or anti-estrogen for Bologna poor responders? Gynecological Endocrinology, 31(12), 955–958. https://doi.org/10.3109/09513590.2015.1081166
dc.identifier.issn0951-3590
dc.identifier.issn1473-0766
dc.identifier.urihttps://doi.org/10.3109/09513590.2015.1081166
dc.identifier.urihttps://hdl.handle.net/20.500.14065/2744
dc.description.abstractThe current study aims to compare cycle outcomes of two ovarian stimulation protocols in poor responders according to the Bologna criteria; luteal estrogen priming (LE) or letrozole (LZ) co-treatment in antagonist protocol. Following retrospective chart review of a single center, 162 cycles were found eligible for the comparison of two ovarian stimulation protocols. After interpreting data, significantly higher serum estradiol levels, longer duration of cycle, higher number of fertilized oocytes and good quality embryos were detected in patients who received LE. Despite any statistical significance, higher clinical pregnancy rate (CPR) and ongoing pregnancy rate (OPR) per embryo transfer (ET) were detected with LE protocol compared with LZ (12.3% versus 18.2% and 9.6% versus 12.7%, respectively). Younger patients (<40 years) revealed higher CPR and OPR per started cycle compared with older patients (>= 40 years) where only OPR was statistically significant. Multivariable analysis demonstrated that basal antral follicle count, peak serum estradiol levels and number of fertilized oocytes were independent variables significantly associated with clinical pregnancies (p<0.05). In the current analysis, LE or LZ protocols revealed comparable but quite low pregnancy rates in poor responders according to the Bologna criteria. Younger patients were more likely to achieve pregnancy compared to older patients with both protocols.en_US
dc.language.isoengen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofGynecological Endocrinologyen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBologna criteriaen_US
dc.subjectLetrozoleen_US
dc.subjectLuteal estrogenen_US
dc.subjectPoor responderen_US
dc.subjectLuteal estradiol pretreatmenten_US
dc.subjectIn-vitro fertilizationen_US
dc.subjectOvarian responseen_US
dc.subjectProtocolen_US
dc.subjectIvfen_US
dc.subjectLetrozoleen_US
dc.subjectAromataseen_US
dc.subjectWomenen_US
dc.subjectGonadotropinsen_US
dc.subjectStimulationen_US
dc.titleEstrogen or anti-estrogen for Bologna poor responders?en_US
dc.typearticleen_US
dc.authoridPabuçcu, Recai / 0000-0003-4563-3592
dc.authoridÇağlar, Gamze Sinem / 0000-0003-1956-0908
dc.departmentTıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Kadın Hastalıkları ve Doğumen_US
dc.institutionauthorPabuçcu, Emre Göksan
dc.institutionauthorPabuçcu, Recai
dc.institutionauthorÇağlar, Gamze Sinem
dc.identifier.doi10.3109/09513590.2015.1081166
dc.identifier.volume31en_US
dc.identifier.issue12en_US
dc.identifier.startpage955en_US
dc.identifier.endpage958en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.authorscopusid35734773800
dc.authorscopusid55879368100
dc.authorscopusid18635130700
dc.identifier.wosWOS:000366349300010en_US
dc.identifier.scopus2-s2.0-84951567669en_US
dc.identifier.pmid26361802en_US


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