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dc.contributor.authorBeriat, Güçlü Kaan
dc.contributor.authorAkmansu, Şefik Halit
dc.contributor.authorDoğan, Cem
dc.contributor.authorEzerarslan, Hande
dc.contributor.authorHan, Ünsal
dc.contributor.authorSağlam, Mehmet
dc.contributor.authorKocatürk, Sinan
dc.date.accessioned2022-03-10T19:33:06Z
dc.date.available2022-03-10T19:33:06Z
dc.date.issued2012
dc.identifier.citationBeriat, G.K., Akmansu, S.H., Dogan, C., Ezerarslan, H., Han, U., Saglam, M., Okan Senel, O., & Kocaturk, S. (2012). The effect of subcutaneous Insulin-like Growth Factor-1 (IGF-1) injection on rabbit auricular cartilage autograft viability. Bosnian Journal of Basic Medical Sciences, 12(4), 213. https://doi.org/10.17305/bjbms.2012.2440
dc.identifier.issn1512-8601
dc.identifier.urihttps://hdl.handle.net/20.500.14065/3095
dc.description.abstractInsulin-like Growth Factor-1 (IGF-1.) is one of the significant substances affecting the growth and development of cartilage tissue in the body. The aim of this study is to evaluate the possible histopathological effects of local IGF-1 injection on the viability of rabbit auricular cartilage autografts. To this end, the single-piece and sliced cartilage tissues obtained from 20 albino rabbits' auricula were implanted in the subcutaneous pockets created on the back skins of the experimental animals. Every two weeks IGF-1 (10 mg/ml) injections were performed on the autograft implants of one group and normal saline (0.9%) injections were performed on the other group. Experimental animals were sacrificed at the end of the third month. A total of 34 tissue samples obtained after dissection were evaluated and scored histopathologically according to their cartilage viability, environmental reaction, and regenerative activities. The intergroup evaluation carried out for the single-piece and sliced cartilage grafts revealed that there was statistically more cartilage viability and less foreign-body reaction in the IGF-1 group than the normal saline group (p<0.05). While there was a statistically significant difference between the groups for single-piece grafts regarding regenerative activity (p<0.05), there was no significant difference for sliced grafts. The IGF-1 group, however, showed more activity. The results we obtained point out to the fact that IGF-1 increases the tissue viability of the implanted auricular autograft and it suppresses immune modulation effect. (C) 2012 Association of Basic Medical Sciences of FBH. All rights reserveden_US
dc.language.isoengen_US
dc.publisherAssoc Basic Medical Sci Federation Bosnia & Herzegovina Sarajevoen_US
dc.relation.ispartofBosnian Journal of Basic Medical Sciencesen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAuricleen_US
dc.subjectRabbiten_US
dc.subjectCartilageen_US
dc.subjectAutograften_US
dc.subjectIGF-1en_US
dc.subjectChondrocytesen_US
dc.subjectSystemen_US
dc.subjectModelen_US
dc.subjectAxisen_US
dc.titleThe effect of subcutaneous Insulin-like Growth Factor-1 (IGF-1) injection on rabbit auricular cartilage autograft viabilityen_US
dc.typearticleen_US
dc.authoridDoğan, Cem / 0000-0003-2202-9835
dc.authoridBeriat, Güçlü Kaan / 0000-0003-1483-528X
dc.authoridAkmansu, Şefik Halit / 0000-0001-8100-0165
dc.authoridKocatürk, Sinan / 0000-0002-0322-8452
dc.departmentTıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Kulak Burun Boğaz Hastalıklarıen_US
dc.institutionauthorBeriat, Güçlü Kaan
dc.institutionauthorAkmansu, Şefik Halit
dc.institutionauthorDoğan, Cem
dc.institutionauthorEzerarslan, Hande
dc.institutionauthorKocatürk, Sinan
dc.identifier.volume12en_US
dc.identifier.issue4en_US
dc.identifier.startpage213en_US
dc.identifier.endpage218en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.authorwosidDoğan, Cem / AAS-5677-2020
dc.authorscopusid36522196500
dc.authorscopusid36698656500
dc.authorscopusid54928344800
dc.authorscopusid37008164900
dc.authorscopusid55913693600
dc.authorscopusid56720456800
dc.authorscopusid46461641500
dc.identifier.wosqualityQ3
dc.identifier.wosWOS:000313399000002en_US
dc.identifier.scopus2-s2.0-84871678248en_US
dc.identifier.pmid23198934en_US


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