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dc.contributor.authorKaracaoğlan, Volkan
dc.contributor.authorAda, Ahmet Oğuz
dc.contributor.authorBilgen, Serdar
dc.contributor.authorÇetinkaya, Güzide Tuğba
dc.contributor.authorSoydaş, Emre
dc.contributor.authorKunak, Celalettin Semih
dc.contributor.authorAlpar, Sibel Meryem
dc.contributor.authorGülhan, Meral
dc.contributor.authorİşcan, Mümtaz
dc.description.abstractBackground/aim: The association between polymorphisms of xenobiotic/drug metabolizing enzymes and TP53 and response to chemotherapy and survival of patients with nonsmall cell lung cancer (NSCLC) are limited and inconclusive. In this study, CYP2E1*5B, CYP2E1*6, CYP2E1*7B, GSTO1 (A140D), and TP53 (Arg72Pro) polymorphisms and response to platinum-based chemotherapy and survival in 137 advanced stage NSCLC patients were investigated. Materials and methods: Genetic polymorphism analyses were determined by polymerase chain reaction (PCR) coupled with restriction fragment length polymorphism (RFLP). Results: The patients with TP53 Pro/Pro variant were more likely to be resistant to chemotherapy than those with Arg/Arg variants with marginal significance (P = 0.066). We also analyzed these gene variants in combination with CYP1A1 (Ile462Val), CYP1B1 (Asn453Ser), GSTM1, GSTP1 exon 5 (Ile105Val), and GSTP1 exon 6 (Ala114Val) and GSTT1 polymorphic genes that we have previously genotyped in the same patients (Ada et al., Neoplasma, 57, 512-527, 2010). The multivariate analysis revealed that adjusted hazard ratio (HR) of death of the combined variant genotypes of TP53 (Arg72Pro, Pro72Pro) and CYP1A1 (Ile462Val, Val462Val) increased significantly as compared to wild-type genotypes (HR, 6.03; 95% CI, 1.39–26.04, P = 0.016). Conclusion: These results show that combined variant genotypes of TP53 (Arg72Pro, Pro72Pro) and CYP1A1 (Ile/Val, Val/Val) are associated with worsening of survival in NSCLC patients.en_US
dc.relation.ispartofseriesTurkish Journal of Medical Sciences (47);554-562
dc.subjectXenobiotic/drug metabolizing enzymesen_US
dc.subjectresponse to chemotherapyen_US
dc.subjectnonsmall cell lung canceren_US
dc.titleXenobiotic/drug metabolizing enzyme and TP53 polymorphisms and clinical outcome in advanced nonsmall cell lung cancer patientsen_US
dc.departmentTıp Fakültesien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US

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