Relation between clinical, histopathological properties and microvessel density assessed by CD105 and CD31 in prostate carcinoma
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Introduction: We designed this study in order to investigate the relation between histopathological and clinical properties in prostatic carcinoma patients and microvessel density (MVD) of tumoral and peritumoral tissue, assessed by CD105 and CD31 expression. Methods: A total of 100 radical prostatectomy samples, have been evaluated retrospectively with clinical and histopathological findings. Immunohistochemical markers of CD105 and CD31 were applied to the tumoral tissue and surroundings of tumor. Relation between tumoral and peritumoral CD105, CD31 and clinical or histopathological findings was evaluated. Results: CD105 and CD31 together with MVD have been found more significant in the tumoral tissue than the periphery (p<0,001). CD105 expression in the peritumoral tissue was significantly lower than the CD31 expression. A significant correlation has been found between CD105 MVD in the tumoral tissue and the preoperative serum total PSA levels and tumor volume (r=0.259, p=0.009, r=0.198, p=0.049, respectively). Tumoral CD105 expression was significantly higher in cases with perineural invasion, lymph node metastasis and local invasion (p=0.003, p=0.009, p=0.044). CD31 expression was significantly correlated with pathological stage (r=0.228, p= 0.022, p=0,034, respectively). Cases with seminal vesicle invasion and extracapsular extension had with significantly higher CD31 MVD. No significant correlation was found between peritumoral tissue MVD and clinical or histopathological findings. Discussion and Conclusion: Finding of association between CD105 and CD31 in the tumoral tissue and prognostic clinical findings, supports the importance of angiogenesis in tumoral progression. This may reveal new treatment modalities for research involving anti-angiogenic agents.